There is much information that my biochemistry class has discussed since the beginning of the semester that pertain to, and gather results and background information, from classes that I have previously taken. Some of these classes include, but are not limited to, General Biology 1 & 2, General Chemistry, Organic Chemistry, and Genetics. These classes served as an excellent background for this course. Recent covered material in biochemistry had to do with enzymes as inhibitors and activators. I was first introduced to enzymes back in general chemistry during my first year away at school. More general chemistry background was connected to our discussion of water, its properties, and how important it is in biochemistry. Material I am currently discussing in genetics is connected with biochemistry through DNA and proteins. The processes and functions of proteins that genetics covers are discussed in biochemistry as well as amino acid structure and much more.
So far I am interested in what I have learned and I am thankful that I have the background information from previous science classes to encourage and support the new material that is being introduced.
Thursday, February 25, 2010
PDB Explorer Protein: Discription, Disease, and Real World Application.
The protein that I found interesting is called the Human Papillomavirus E2 Protein Type 16. Its pdb ID is IDTO. Many people have heard of HPV and the infection that it can cause. It is one of the most common sexually transmitted infections we know about today (cdc.gov). HPV Type 16 belongs to the papillomavirus E2 protein family and is located on the E2 gene.
This E2 gene is chain A and its function deals with nucleotide and DNA binding. Its processes are DNA replication and transcription. The E1-E2 protein complex binds to the the origin of DNA replication which allows it to regulate the replication by either activating or repressing transcription depending on its position.
Works cited:
www.cdc.gov/hpv/WhatIsHPV.html
http://www.ebi.ac.uk/msd-srv/oca/oca-bin/ocaids
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